{"id":190085,"date":"2026-10-01T11:27:13","date_gmt":"2026-10-01T11:27:13","guid":{"rendered":"https:\/\/af.dawatmedia24.com\/?p=190085"},"modified":"2026-10-01T11:27:13","modified_gmt":"2026-10-01T11:27:13","slug":"%da%85%d9%87-%d8%af%d9%8a%d8%9ftp53-%d8%a7%d9%88-p53","status":"publish","type":"post","link":"https:\/\/af.dawatmedia24.com\/?p=190085","title":{"rendered":"\u0685\u0647 \u062f\u064a\u061fTP53 \u0627\u0648 p53"},"content":{"rendered":"<div dir=\"ltr\">\n<div dir=\"rtl\">\n<div>\n<h3 dir=\"ltr\" style=\"text-align: center;\"><span style=\"color: #800000;\"><strong><span dir=\"rtl\">TP53 \u0627\u0648 p53 \u0685\u0647 \u062f\u064a\u061f<\/span><\/strong><\/span><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<div dir=\"ltr\">\n<div dir=\"rtl\">\n<div>\n<p style=\"text-align: center;\"><strong><span style=\"color: #ff6600;\">\u062f \u0633\u0631\u0637\u0627\u0646 \u0637\u0628\u06cc\u0639\u064a \u062f\u069a\u0645\u0646 \u0685\u0646\u06ab\u0647 \u062f \u0646\u0648\u06d0 \u0647\u062f\u0641\u0645\u0646\u062f\u06d0 \u062f\u0631\u0645\u0644\u0646\u06d0 \u067e\u0647 \u062f\u0631\u0648\u0627\u0632\u0647 \u0628\u062f\u0644 \u0634\u0648\u061f<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: #ff6600;\">\u0644\u0647 \u06f1\u06f9\u06f7\u06f9 \u06a9\u0634\u0641 \u0685\u062e\u0647 \u062a\u0631 \u06f2\u06f0\u06f2\u06f6 \u067e\u0648\u0631\u06d0: Rezatapopt\u060c ctDNA \u0627\u0648 ADCs &#8211; \u0685\u0647 \u062b\u0627\u0628\u062a \u062f\u064a\u060c \u0685\u0647 \u0647\u06cc\u0644\u0647\u200c\u0645\u0646 \u062f\u064a\u060c \u0627\u0648 \u0685\u0647 \u0644\u0627 \u0685\u06d0\u0693\u0646\u06cc\u0632 \u062f\u064a\u061f<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div dir=\"auto\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u062f \u00a0Peer-reviewed \u0685\u06d0\u0693\u0646\u0648 \u0627\u0648 \u0631\u0633\u0645\u064a \u062c\u06cc\u0646\u064a \u0633\u0631\u0686\u06cc\u0646\u0648 \u067e\u0631 \u0628\u0646\u0633\u067c \u0644\u06cc\u06a9\u0646\u0647<\/div>\n<div dir=\"rtl\">\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: Noto Naskh Arabic;\"><b>\u06f3\u06f0 \u0633\u067e\u062a\u0645\u0628\u0631 \u06f2\u06f0\u06f2\u06f6<\/b><\/span><\/p>\n<p>\u06f1. \u0648\u0644\u06d0 \u062f\u0627 \u0645\u0648\u0636\u0648\u0639 \u0646\u0646 \u0628\u06cc\u0627 \u062f \u0628\u062d\u062b \u0648\u0693 \u062f\u0647\u061f<\/p>\n<p>\u067e\u0647 \u0648\u0631\u0648\u0633\u062a\u06cc\u0648 \u06a9\u0644\u0648\u0646\u0648 \u06a9\u06d0 \u062f TP53\u060c p53\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0648 \u062d\u062a\u06cc \u062f \u0648\u0627\u06a9\u0633\u06cc\u0646\u0648\u0646\u0648 \u067e\u0647 \u0627\u0693\u0647 \u06ab\u06bc\u06d0 \u0627\u062f\u0639\u0627\u0648\u06d0 \u067e\u0647 \u0631\u0633\u0646\u06cc\u0648 \u0627\u0648 \u067c\u0648\u0644\u0646\u06cc\u0632\u0648 \u0634\u0628\u06a9\u0648 \u06a9\u06d0 \u0633\u0631\u0647 \u06ab\u0689\u06d0 \u0634\u0648\u06d0 \u062f\u064a.<\/p>\n<p>\u062f \u062f\u06d0 \u0628\u062d\u062b \u062f \u0633\u0645\u067e\u0648 \u0647\u06cc\u062f\u0648 \u0644\u067e\u0627\u0631\u0647 \u062a\u0631 \u0647\u0631 \u0685\u0647 \u0645\u062e\u06a9\u06d0 \u0628\u0627\u06cc\u062f \u0628\u0646\u0633\u067c\u06cc\u0632\u0647 \u067e\u0648\u069a\u062a\u0646\u0647 \u0631\u0648\u069a\u0627\u0646\u0647 \u0634\u064a:<\/p>\n<p>TP53 \u0685\u0647 \u0634\u06cc \u062f\u06cc\u060c p53 \u0685\u0647 \u0634\u06cc \u062f\u06cc\u060c \u0627\u0648 \u0633\u0627\u06cc\u0646\u0633 \u0644\u0648\u0645\u0693\u06cc \u062f\u0627 \u0633\u06cc\u0633\u062a\u0645 \u0685\u0646\u06ab\u0647 \u0648\u067e\u06d0\u0698\u0627\u0646\u062f\u061f<\/p>\n<p>\u06a9\u0647 \u062f\u0627 \u0628\u0646\u0633\u067c \u0633\u0645 \u0648\u067e\u06d0\u0698\u0646\u0648\u060c \u0648\u0631\u0648\u0633\u062a\u0647 \u06a9\u0648\u0644\u0627\u06cc \u0634\u0648 \u062f \u0641\u06cc\u0644\u0627\u0646\u0648\u060c \u0633\u0631\u0637\u0627\u0646\u060c \u0648\u0627\u06a9\u0633\u06cc\u0646\u0648\u0646\u0648 \u0627\u0648 \u0646\u0648\u0631\u0648 \u0627\u062f\u0639\u0627\u0648\u0648 \u0639\u0644\u0645\u064a \u0627\u0631\u0632\u0648\u0646\u0647 \u0647\u0645 \u0644\u0647 \u0627\u062d\u0633\u0627\u0633\u0627\u062a\u0648 \u067e\u0631\u062a\u0647 \u0648\u06a9\u0693\u0648.<\/p>\n<p>\u06f2. TP53 \u0627\u0648 p53 \u06cc\u0648 \u0634\u06cc \u062f\u064a\u060c \u06a9\u0647 \u062f\u0648\u0647 \u0628\u06d0\u0644\u0627\u0628\u06d0\u0644 \u062c\u06cc\u0646\u0648\u0646\u0647\u061f<\/p>\n<p>\u062f \u0627\u0646\u0633\u0627\u0646 \u062f \u062c\u06cc\u0646 \u0631\u0633\u0645\u064a \u0646\u0648\u0645 TP53 \u062f\u06cc. \u062f\u0627 \u062c\u06cc\u0646 \u062f \u06f1\u06f7\u0645 \u06a9\u0631\u0648\u0645\u0648\u0632\u0648\u0645 \u067e\u0647 \u0644\u0646\u0689 \u0628\u0627\u0632\u0648\u060c 17p13.1 \u0633\u06cc\u0645\u0647 \u06a9\u06d0 \u0645\u0648\u0642\u0639\u06cc\u062a \u0644\u0631\u064a. TP53 \u062f \u06cc\u0648\u0647 \u067e\u0631\u0648\u067c\u06cc\u0646 \u062f \u062c\u0648\u0693\u06d0\u062f\u0648 \u0644\u0627\u0631\u069a\u0648\u0648\u0646\u0647 \u06a9\u0648\u064a \u0686\u06d0 p53 \u0646\u0648\u0645\u06d0\u0696\u064a. \u0646\u0648 \u067e\u0647 \u0633\u0627\u062f\u0647 \u0698\u0628\u0647: TP53 \u062c\u06cc\u0646 \u062f\u06cc\u060c \u0627\u0648 p53 \u062f \u0647\u0645\u062f\u06d0 \u062c\u06cc\u0646 \u067e\u0631\u0648\u067c\u06cc\u0646\u064a \u0645\u062d\u0635\u0648\u0644 \u062f\u06cc. \u067e\u0647 \u067e\u062e\u0648\u0627\u0646\u06cc\u0648 \u0639\u0644\u0645\u064a \u0645\u0642\u0627\u0644\u0648 \u06a9\u06d0 \u06a9\u0644\u0647 \u0646\u0627\u06a9\u0644\u0647 \u201cp53 gene\u201d \u0647\u0645 \u0644\u06cc\u06a9\u0644 \u0634\u0648\u06cc\u061b \u062e\u0648 \u062f \u0627\u0646\u0633\u0627\u0646 \u062f \u062c\u06cc\u0646 \u0631\u0633\u0645\u064a \u0633\u0645\u0628\u0648\u0644 TP53 \u062f\u06cc. [5]<\/p>\n<p>\u06f3. p53 \u0644\u0648\u0645\u0693\u06cc \u0686\u0627 \u0648\u0645\u0648\u0646\u062f\u061f<\/p>\n<p>\u062f p53 \u06a9\u0634\u0641 \u062f \u06cc\u0648\u0647 \u0648\u0627\u062d\u062f \u0633\u0627\u06cc\u0646\u0633\u067e\u0648\u0647 \u06a9\u0627\u0631 \u0646\u0647 \u0648. \u067e\u0647 \u06f1\u06f9\u06f7\u06f9 \u06a9\u0627\u0644 \u06a9\u06d0 \u0685\u0648 \u062e\u067e\u0644\u0648\u0627\u06a9\u0648 \u0685\u06d0\u0693\u0646\u06cc\u0632\u0648 \u0689\u0644\u0648\u060c \u062f SV40 \u0648\u06cc\u0631\u0648\u0633 \u0627\u0648 \u0633\u0631\u0637\u0627\u0646\u064a \u0628\u062f\u0644\u0648\u0646 \u062f \u0645\u0637\u0627\u0644\u0639\u06d0 \u067e\u0631 \u0645\u0647\u0627\u0644\u060c \u0646\u0696\u062f\u06d0 \u067e\u0647 \u06cc\u0648 \u0648\u062e\u062a \u06a9\u06d0 \u062f\u06d0 \u067e\u0631\u0648\u067c\u06cc\u0646 \u062a\u0647 \u0648\u0631\u0633\u06d0\u062f\u06d0. David Lane \u0627\u0648 Lionel Crawford \u062f \u06f1\u06f9\u06f7\u06f9 \u062f \u0645\u0627\u0631\u0686 \u067e\u0647 Nature \u06a9\u06d0 \u0648\u069a\u0648\u062f\u0644\u0647 \u0686\u06d0 \u062f SV40 \u0644\u0648\u06cc T-antigen \u062f \u06a9\u0648\u0631\u0628\u0647 \u062d\u062c\u0631\u06d0 \u0644\u0647 \u06cc\u0648\u0647 \u0681\u0627\u0646\u06ab\u0693\u064a \u067e\u0631\u0648\u067c\u06cc\u0646 \u0633\u0631\u0647 \u062a\u0693\u0644 \u06a9\u06d0\u0696\u064a. \u0647\u0645\u0627\u063a\u0647 \u06a9\u0627\u0644 Daniel Linzer \u0627\u0648 Arnold Levine \u067e\u0647 Cell \u06a9\u06d0 \u062f \u0634\u0627\u0648\u062e\u0648\u0627 54-kDa \u062d\u062c\u0631\u0648\u064a \u067e\u0631\u0648\u067c\u06cc\u0646 \u0681\u0627\u0646\u06ab\u0693\u0646\u06d0 \u062a\u0634\u0631\u06cc\u062d \u06a9\u0693\u06d0\u060c \u0627\u0648 Albert DeLeo\u060c Lloyd Old \u0627\u0648 \u0647\u0645\u06a9\u0627\u0631\u0627\u0646\u0648 \u067e\u0647 PNAS \u06a9\u06d0 \u0648\u0631\u062a\u0647 \u067e\u0631\u0648\u067c\u06cc\u0646 \u067e\u0647 \u06a9\u06cc\u0645\u06cc\u0627\u0648\u064a \u0689\u0648\u0644 \u0631\u0627\u0645\u0646\u0681\u062a\u0647 \u0634\u0648\u0648 \u062a\u0648\u0645\u0648\u0631\u0648\u0646\u0648 \u06a9\u06d0 \u0648\u0645\u0648\u0646\u062f. \u0644\u0647 \u0647\u0645\u062f\u06d0 \u0627\u0645\u0644\u0647 \u0639\u0644\u0645\u064a \u062a\u0627\u0631\u06cc\u062e p53 \u062f \u0685\u0648 \u062e\u067e\u0644\u0648\u0627\u06a9\u0648 \u0689\u0644\u0648 \u06ab\u0689 \u06a9\u0634\u0641 \u06ab\u06bc\u064a\u060c \u0646\u0647 \u062f \u06cc\u0648\u0647 \u06a9\u0633 \u0627\u0646\u062d\u0635\u0627\u0631\u064a \u0645\u0648\u0646\u062f\u0646\u0647. [1\u20133]<\/p>\n<p>\u06f4. \u0648\u0644\u06d0 \u0648\u0631\u062a\u0647 p53 \u0648\u0648\u06cc\u0644 \u0634\u0648\u0644\u061f<\/p>\n<p>\u0646\u0648\u0645 \u06cc\u06d0 \u062f \u067e\u0631\u0648\u067c\u06cc\u0646 \u0644\u0647 \u0627\u067c\u06a9\u0644\u064a \u0645\u0627\u0644\u06cc\u06a9\u0648\u0644\u064a \u0648\u0632\u0646 \u0685\u062e\u0647 \u0631\u0627\u063a\u06cc. \u067e\u0647 \u0644\u0648\u0645\u0693\u0646\u06cc\u0648 \u062a\u062c\u0631\u0628\u0648 \u06a9\u06d0 \u062f\u0627 \u067e\u0631\u0648\u067c\u06cc\u0646 \u062f \u062c\u06d0\u0644 \u0627\u0644\u06a9\u062a\u0631\u0641\u0648\u0631\u06d0\u0632 \u067e\u0631 \u0645\u0647\u0627\u0644 \u0646\u0696\u062f\u06d0 53 \u06a9\u06cc\u0644\u0648\u0689\u0627\u0644\u067c\u0646 (kDa) \u069a\u06a9\u0627\u0631\u0647 \u06a9\u06d0\u062f\u0647\u060c \u0646\u0648 \u062f \u201cprotein 53\u201d \u06cc\u0627 p53 \u0646\u0648\u0645 \u067e\u0631\u06d0 \u06a9\u06d0\u069a\u0648\u062f\u0644 \u0634\u0648. \u0648\u0631\u0648\u0633\u062a\u0647 \u062f \u062f\u06d0 \u067e\u0631\u0648\u067c\u06cc\u0646 \u0645\u0627\u0644\u06cc\u06a9\u0648\u0644\u064a \u0627\u0648 \u062c\u06cc\u0646\u064a \u0681\u0627\u0646\u06ab\u0693\u0646\u06d0 \u0689\u06d0\u0631\u06d0 \u062f\u0642\u06cc\u0642\u06d0 \u0648\u067e\u06d0\u0698\u0646\u062f\u0644 \u0634\u0648\u06d0\u060c \u062e\u0648 \u062a\u0627\u0631\u06cc\u062e\u064a \u0646\u0648\u0645 p53 \u067e\u0627\u062a\u06d0 \u0634\u0648.<\/p>\n<p>\u06f5. \u0622\u06cc\u0627 TP53 \u0633\u0631\u0637\u0627\u0646 \u062c\u0648\u0693\u0648\u064a\u060c \u06a9\u0647 \u062f \u0633\u0631\u0637\u0627\u0646 \u0645\u062e\u0647 \u0646\u06cc\u0633\u064a\u061f<\/p>\n<p>\u067e\u0647 \u0646\u0648\u0631\u0645\u0627\u0644 \u062d\u0627\u0644\u062a \u06a9\u06d0 TP53 \u062f \u0633\u0631\u0637\u0627\u0646 \u062f \u0631\u0627\u0645\u0646\u0681\u062a\u0647 \u06a9\u0648\u0644\u0648 \u062c\u06cc\u0646 \u0646\u0647 \u062f\u06cc\u061b \u0628\u0631\u0639\u06a9\u0633\u060c \u062f \u0628\u062f\u0646 \u0644\u0647 \u0645\u0647\u0645\u0648 Tumor Suppressor Genes \u0685\u062e\u0647 \u062f\u06cc. \u06a9\u0644\u0647 \u0686\u06d0 \u062f \u062d\u062c\u0631\u06d0 DNA \u0632\u06cc\u0627\u0646\u0645\u0646 \u0634\u064a\u060c p53 \u062f \u062d\u062c\u0631\u06d0 \u062f \u0648\u06d0\u0634 \u0628\u0647\u06cc\u0631 \u062f\u0631\u0648\u0644\u0627\u06cc \u0634\u064a\u060c \u062f DNA \u062f \u062a\u0631\u0645\u06cc\u0645 \u0644\u067e\u0627\u0631\u0647 \u0648\u062e\u062a \u0628\u0631\u0627\u0628\u0631\u0648\u0644\u0627\u06cc \u0634\u064a\u060c \u0627\u0648 \u06a9\u0647 \u0632\u06cc\u0627\u0646 \u0689\u06d0\u0631 \u062c\u062f\u064a \u0627\u0648 \u062f \u062a\u0631\u0645\u06cc\u0645 \u0648\u0693 \u0646\u0647 \u0648\u064a\u060c \u062d\u062c\u0631\u0647 \u062f \u067e\u0631\u0648\u06ab\u0631\u0627\u0645 \u0634\u0648\u06d0 \u0645\u0693\u06cc\u0646\u06d0 \u06cc\u0627 Apoptosis \u067e\u0631 \u0644\u0648\u0631 \u0628\u06cc\u0648\u0644\u0627\u06cc \u0634\u064a. p53 \u0647\u0645\u062f\u0627\u0631\u0646\u06ab\u0647 \u062f cellular senescence \u0627\u0648 \u06cc\u0648 \u0634\u0645\u06d0\u0631 \u0646\u0648\u0631\u0648 \u062f\u0641\u0627\u0639\u064a \u067e\u0631\u0648\u06ab\u0631\u0627\u0645\u0648\u0646\u0648 \u067e\u0647 \u062a\u0646\u0638\u06cc\u0645 \u06a9\u06d0 \u0628\u0631\u062e\u0647 \u0644\u0631\u064a. \u0647\u0645\u062f\u06d0 \u062d\u0641\u0627\u0638\u062a\u064a \u0646\u0642\u0634 p53 \u062a\u0647 \u062f \u201cGuardian of the Genome\u201d \u06cc\u0627 \u062f \u062c\u06cc\u0646\u0648\u0645 \u062f \u0633\u0627\u062a\u0648\u0646\u06a9\u064a \u0645\u0634\u0647\u0648\u0631 \u0639\u0644\u0645\u064a \u0646\u0648\u0645 \u0648\u0631\u06a9\u0693\u06cc \u062f\u06cc. [5,6]<\/p>\n<p>\u06f6. \u0646\u0648 p53 \u0648\u0644\u06d0 \u062f \u0633\u0631\u0637\u0627\u0646 \u067e\u0647 \u0689\u06d0\u0631\u0648 \u062a\u0648\u0645\u0648\u0631\u0648\u0646\u0648 \u06a9\u06d0 \u06cc\u0627\u062f\u06d0\u0696\u064a\u061f<\/p>\n<p>\u0633\u062a\u0648\u0646\u0632\u0647 \u0647\u063a\u0647 \u0648\u062e\u062a \u067e\u06cc\u062f\u0627 \u06a9\u06d0\u0696\u064a \u0686\u06d0 TP53 \u062c\u06cc\u0646 \u062e\u067e\u0644\u0647 \u0628\u062f\u0644\u0648\u0646 (mutation) \u0648\u0645\u0648\u0645\u064a\u060c \u0644\u0647 \u0645\u0646\u0681\u0647 \u0648\u0644\u0627\u0693 \u0634\u064a\u060c \u06cc\u0627 \u062f p53 \u067e\u0631\u0648\u067c\u06cc\u0646 \u0641\u0639\u0627\u0644\u06cc\u062a \u067e\u0647 \u0628\u0644\u0647 \u0644\u0627\u0631\u0647 \u06a9\u0645\u0632\u0648\u0631\u06cc \u0634\u064a. \u067e\u0647 \u062f\u0627\u0633\u06d0 \u062d\u0627\u0644\u062a \u06a9\u06d0 \u06cc\u0648\u0647 \u0632\u06cc\u0627\u0646\u0645\u0646\u0647 \u062d\u062c\u0631\u0647 \u0645\u0645\u06a9\u0646 \u062f \u0648\u06d0\u0634 \u0644\u0647 \u06a9\u0646\u067c\u0631\u0648\u0644\u0647 \u0648\u0648\u0681\u064a \u0627\u0648 \u0646\u0648\u0631\u06d0 \u062c\u06cc\u0646\u064a \u062a\u06d0\u0631\u0648\u062a\u0646\u06d0 \u0647\u0645 \u0631\u0627\u067c\u0648\u0644\u06d0 \u06a9\u0693\u064a. \u062f \u0627\u0646\u0633\u0627\u0646 \u062f \u0633\u0631\u0637\u0627\u0646\u0648\u0646\u0648 \u0646\u0696\u062f\u06d0 \u0646\u06cc\u0645\u0627\u06cc\u064a \u06a9\u06d0 \u062f TP53 \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0647 \u0644\u06cc\u062f\u0644 \u06a9\u06d0\u0696\u064a\u061b \u062e\u0648 \u062f \u0628\u062f\u0644\u0648\u0646 \u0689\u0648\u0644\u060c \u062f \u062a\u0648\u0645\u0648\u0631 \u0646\u0648\u0639\u0647 \u0627\u0648 \u062f \u0647\u063a\u0647 \u0628\u06cc\u0648\u0644\u0648\u0698\u064a \u06cc\u0648 \u0644\u0647 \u0628\u0644 \u0633\u0631\u0647 \u062a\u0648\u067e\u06cc\u0631 \u0644\u0631\u064a. \u062f \u06f1\u06f9\u06f8\u06f0\u0645\u06d0 \u0644\u0633\u06cc\u0632\u06d0 \u067e\u0647 \u067e\u0627\u06cc \u06a9\u06d0 \u062f \u0627\u0646\u0633\u0627\u0646 \u062f \u0633\u0631\u0637\u0627\u0646\u0648\u0646\u0648 \u062c\u06cc\u0646\u064a \u0685\u06d0\u0693\u0646\u0648\u060c \u067e\u0647 \u0681\u0627\u0646\u06ab\u0693\u064a \u0689\u0648\u0644 \u062f \u06a9\u0648\u0644\u0648\u0631\u06a9\u067c\u0627\u0644 \u0633\u0631\u0637\u0627\u0646 \u0645\u0637\u0627\u0644\u0639\u0627\u062a\u0648\u060c \u0648\u069a\u0648\u062f\u0644\u0647 \u0686\u06d0 \u062f TP53 \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0647 \u062f \u062a\u0648\u0645\u0648\u0631 \u062f \u067e\u0631\u0645\u062e\u062a\u06ab \u0644\u0647 \u0645\u0647\u0645\u0648 \u067e\u06d0\u069a\u0648 \u0685\u062e\u0647 \u062f\u064a. [4]<\/p>\n<p>\u06f7. \u0622\u06cc\u0627 \u0633\u0627\u06cc\u0646\u0633 \u0644\u0647 \u0644\u0648\u0645\u0693\u06cd \u0648\u0631\u0681\u06d0 \u067e\u0648\u0647\u06d0\u062f\u0647 \u0686\u06d0 p53 \u062f \u062a\u0648\u0645\u0648\u0631 \u0636\u062f \u0633\u06cc\u0633\u062a\u0645 \u062f\u06cc\u061f<\/p>\n<p>\u0646\u0647. \u062f p53 \u062f \u0685\u06d0\u0693\u0646\u06d0 \u062a\u0627\u0631\u06cc\u062e \u062e\u067e\u0644\u0647 \u062f \u0633\u0627\u06cc\u0646\u0633 \u06cc\u0648\u0647 \u067e\u0647 \u0632\u0693\u0647 \u067e\u0648\u0631\u06d0 \u0628\u06d0\u0644\u06ab\u0647 \u062f\u0647. \u067e\u0647 \u0644\u0648\u0645\u0693\u06cc\u0648 \u06a9\u0644\u0648\u0646\u0648 \u06a9\u06d0 \u0681\u06cc\u0646\u0648 \u062a\u062c\u0631\u0628\u0648 \u062f\u0627\u0633\u06d0 \u0627\u0646\u06ab\u06d0\u0631\u0646\u0647 \u067e\u06cc\u062f\u0627 \u06a9\u0693\u0647 \u0686\u06d0 p53 \u069a\u0627\u064a\u064a Oncogene \u0648\u064a\u061b \u0648\u0631\u0648\u0633\u062a\u0647 \u0645\u0639\u0644\u0648\u0645\u0647 \u0634\u0648\u0647 \u0686\u06d0 \u067e\u0647 \u0689\u06d0\u0631\u0648 \u0647\u063a\u0648 \u062a\u062c\u0631\u0628\u0648 \u06a9\u06d0 \u0628\u062f\u0644\u0648\u0646 \u0645\u0648\u0646\u062f\u0644\u06d0 mutant p53 \u0628\u06bc\u06d0 \u06a9\u0627\u0631\u0648\u0644 \u0634\u0648\u06d0 \u0648\u06d0. \u062f \u062c\u06cc\u0646 \u062f \u0646\u0648\u0631\u0645\u0627\u0644 \u0627\u0648 \u0628\u062f\u0644\u0648\u0646 \u0645\u0648\u0646\u062f\u0644\u0648 \u0628\u06bc\u0648 \u062f \u062a\u0648\u067e\u06cc\u0631 \u0644\u0647 \u0631\u0648\u069a\u0627\u0646\u06d0\u062f\u0648 \u0633\u0631\u0647\u060c p53 \u062f \u062a\u0648\u0645\u0648\u0631 \u062f \u0645\u062e\u0646\u06cc\u0648\u064a \u0644\u0647 \u062a\u0631 \u067c\u0648\u0644\u0648 \u0645\u0647\u0645\u0648 \u0633\u06cc\u0633\u062a\u0645\u0648\u0646\u0648 \u0685\u062e\u0647 \u0648\u067e\u06d0\u0698\u0646\u062f\u0644 \u0634\u0648.<\/p>\n<p>\u06f8. \u0622\u06cc\u0627 p53 \u062f \u0633\u0631\u0637\u0627\u0646 \u00ab\u062f\u069a\u0645\u0646\u00bb \u062f\u06cc\u060c \u0627\u0648 \u067e\u0647 \u062f\u0631\u0645\u0644\u0646\u0647 \u06a9\u06d0 \u0685\u0646\u06ab\u0647 \u0645\u0631\u0633\u062a\u0647 \u06a9\u0648\u0644\u0627\u06cc \u0634\u064a\u061f<\/p>\n<p>\u067e\u0647 \u0639\u0644\u0645\u064a \u0645\u0639\u0646\u0627\u060c \u0646\u0648\u0631\u0645\u0627\u0644 p53 \u062e\u067e\u0644\u0647 \u062f\u0631\u0645\u0644 \u0646\u0647 \u062f\u06cc\u061b \u062f\u0627 \u062f \u0628\u062f\u0646 \u06cc\u0648 \u0637\u0628\u06cc\u0639\u064a \u062f \u0633\u0631\u0637\u0627\u0646 \u0636\u062f \u062f\u0641\u0627\u0639\u064a \u067e\u0631\u0648\u067c\u06cc\u0646 \u062f\u06cc. \u062f \u0647\u063a\u0647 \u062f\u0646\u062f\u0647 \u062f\u0627 \u062f\u0647 \u0686\u06d0 \u0632\u06cc\u0627\u0646\u0645\u0646\u06d0 \u062d\u062c\u0631\u06d0 \u0648\u062f\u0631\u0648\u064a\u060c \u062f \u062a\u0631\u0645\u06cc\u0645 \u0644\u067e\u0627\u0631\u0647 \u0648\u062e\u062a \u0648\u0631\u06a9\u0693\u064a\u060c \u06cc\u0627 \u06a9\u0647 \u0632\u06cc\u0627\u0646 \u0646\u0647 \u062c\u0628\u0631\u0627\u0646\u06d0\u0696\u064a\u060c \u062f \u062d\u062c\u0631\u06d0 \u062f \u0645\u0693\u06cc\u0646\u06d0 \u067e\u0631\u0648\u06ab\u0631\u0627\u0645 \u0641\u0639\u0627\u0644 \u06a9\u0693\u064a. \u0644\u0647 \u0647\u0645\u062f\u06d0 \u0627\u0645\u0644\u0647 \u062f \u201c\u0633\u0631\u0637\u0627\u0646 \u0637\u0628\u06cc\u0639\u064a \u062f\u069a\u0645\u0646\u201d \u062a\u0639\u0628\u06cc\u0631 \u062f \u0639\u0627\u0645 \u0641\u0647\u0645 \u0644\u067e\u0627\u0631\u0647 \u0645\u0646\u0627\u0633\u0628 \u062f\u06cc\u060c \u062e\u0648 \u062f\u0642\u06cc\u0642 \u0639\u0644\u0645\u064a \u0627\u0635\u0637\u0644\u0627\u062d \u06cc\u06d0 Tumor Suppressor \u062f\u0647.<\/p>\n<p>\u062f \u062f\u0631\u0645\u0644\u0646\u06d0 \u0646\u0648\u06d0 \u0645\u0641\u06a9\u0648\u0631\u0647 \u062f\u0627 \u062f\u0647: \u06a9\u0647 \u067e\u0647 \u06cc\u0648\u0647 \u062a\u0648\u0645\u0648\u0631 \u06a9\u06d0 p53 \u062f \u0681\u0627\u0646\u06ab\u0693\u064a mutation \u0644\u0647 \u0627\u0645\u0644\u0647 \u062e\u067e\u0644 \u0633\u0645 \u062c\u0648\u0693\u069a\u062a \u0627\u0648 \u0641\u0639\u0627\u0644\u06cc\u062a \u0644\u0647 \u0644\u0627\u0633\u0647 \u0648\u0631\u06a9\u0693\u06cc \u0648\u064a\u060c \u0627\u06cc\u0627 \u06cc\u0648 \u06a9\u0648\u0686\u0646\u06cc \u0645\u0627\u0644\u06cc\u06a9\u0648\u0644 \u06a9\u0648\u0644\u0627\u06cc \u0634\u064a \u0647\u0645\u0627\u063a\u0647 \u062e\u0631\u0627\u0628 \u0634\u0648\u06cc \u067e\u0631\u0648\u067c\u06cc\u0646 \u0628\u06d0\u0631\u062a\u0647 \u062f\u0627\u0633\u06d0 \u062a\u0627\u0648 \u0627\u0648 \u0628\u0627\u062b\u0628\u0627\u062a\u0647 \u06a9\u0693\u064a \u0686\u06d0 \u062f \u0646\u0648\u0631\u0645\u0627\u0644 p53 \u067e\u0647 \u0685\u06d0\u0631 \u06a9\u0627\u0631 \u0648\u06a9\u0693\u064a\u061f \u062f Rezatapopt \u067e\u0647 \u0685\u06d0\u0631 \u062f\u0631\u0645\u0644 \u0647\u0645\u062f\u06d0 \u067e\u0648\u069a\u062a\u0646\u06d0 \u062a\u0647 \u0639\u0645\u0644\u064a \u0681\u0648\u0627\u0628 \u0644\u067c\u0648\u064a. \u0645\u0647\u0645\u0647 \u062e\u0628\u0631\u0647 \u062f\u0627 \u062f\u0647 \u0686\u06d0 \u062f\u0627 \u062a\u06ab\u0644\u0627\u0631\u0647 \u062f \u067c\u0648\u0644\u0648 TP53 mutations \u0644\u067e\u0627\u0631\u0647 \u0646\u0647 \u062f\u0647\u061b \u0641\u0639\u0644\u0627\u064b \u062f \u0681\u0627\u0646\u06ab\u0693\u0648 \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0648 \u0644\u067e\u0627\u0631\u0647 \u062c\u0648\u0693\u0647 \u0634\u0648\u06d0 \u0647\u062f\u0641\u0645\u0646\u062f\u0647 \u062f\u0631\u0645\u0644\u0646\u0647 \u062f\u0647. [7,8]<\/p>\n<p>\u06f9. \u0622\u06cc\u0627 \u062e\u0631\u0627\u0628 \u0634\u0648\u06cc p53 \u0628\u06d0\u0631\u062a\u0647 \u0641\u0639\u0627\u0644\u06d0\u062f\u0627\u06cc \u0634\u064a\u061f<\/p>\n<p>\u062a\u0631 \u0689\u06d0\u0631\u0647 \u0648\u062e\u062a\u0647 p53 \u062f \u062f\u0631\u0645\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u06cc\u0648 \u0689\u06d0\u0631 \u0633\u062a\u0648\u0646\u0632\u0645\u0646 \u0647\u062f\u0641 \u06ab\u06bc\u0644 \u06a9\u06d0\u062f\u0647. \u0627\u0648\u0633 Rezatapopt (PC14586) \u067e\u0647 \u0646\u0648\u0645 \u06cc\u0648 \u06a9\u0648\u0686\u0646\u06cc \u0645\u0627\u0644\u06cc\u06a9\u0648\u0644 \u062f TP53 \u062f Y220C \u0681\u0627\u0646\u06ab\u0693\u064a \u0628\u062f\u0644\u0648\u0646 \u0644\u067e\u0627\u0631\u0647 \u062c\u0648\u0693 \u0634\u0648\u06cc \u062f\u06cc. \u062f\u0627 \u0628\u062f\u0644\u0648\u0646 \u062f p53 \u067e\u0631\u0648\u067c\u06cc\u0646 \u062c\u0648\u0693\u069a\u062a \u06a9\u0645\u0632\u0648\u0631\u06cc \u06a9\u0648\u064a \u0627\u0648 \u067e\u0647 \u067e\u0631\u0648\u067c\u06cc\u0646 \u06a9\u06d0 \u06cc\u0648 \u06a9\u0648\u0686\u0646\u06cc \u201c\u062c\u06cc\u0628\u201d \u06cc\u0627 crevice \u062c\u0648\u0693\u0648\u064a. Rezatapopt \u0644\u0647 \u0647\u0645\u062f\u06d0 \u062c\u06cc\u0628 \u0633\u0631\u0647 \u0646\u069a\u0644\u064a\u060c \u067e\u0631\u0648\u067c\u06cc\u0646 \u0628\u0627\u062b\u0628\u0627\u062a\u0647 \u06a9\u0648\u064a \u0627\u0648 \u0647\u0685\u0647 \u06a9\u0648\u064a \u0686\u06d0 \u062f \u0647\u063a\u0647 \u062f \u062a\u0648\u0645\u0648\u0631 \u0636\u062f \u0641\u0639\u0627\u0644\u06cc\u062a \u0628\u06d0\u0631\u062a\u0647 \u0631\u0627 \u0648\u06ab\u0631\u0681\u0648\u064a. \u067e\u0647 \u06f2\u06f0\u06f2\u06f5 \u06a9\u0627\u0644 \u06a9\u06d0 Cancer Discovery \u06a9\u06d0 preclinical \u0634\u0648\u0627\u0647\u062f \u062e\u067e\u0627\u0631\u0647 \u0634\u0648\u0644\u060c \u0627\u0648 \u062f \u06f2\u06f0\u06f2\u06f6 \u06a9\u0627\u0644 \u067e\u0647 New England Journal of Medicine \u06a9\u06d0 \u062f Phase I \u0645\u0637\u0627\u0644\u0639\u06d0 \u067e\u0627\u06cc\u0644\u06d0 \u062e\u067e\u0631\u06d0 \u0634\u0648\u06d0. [7,8]<\/p>\n<p>\u06f1\u06f0. \u062a\u0631 \u06f2\u06f0\u06f2\u06f6 \u067e\u0648\u0631\u06d0 \u062f\u0627 \u0646\u0648\u06d0 \u0644\u0627\u0631\u0647 \u0685\u0648\u0645\u0631\u0647 \u06a9\u0627\u0645\u06cc\u0627\u0628\u0647 \u0634\u0648\u06d0 \u062f\u0647\u061f<\/p>\n<p>\u062f \u06f2\u06f0\u06f2\u06f6 \u062f Phase I \u0645\u0637\u0627\u0644\u0639\u06d0 \u067e\u0647 \u06f7\u06f7 \u0647\u063a\u0648 \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u06a9\u06d0 \u0686\u06d0 \u067e\u0631\u0645\u062e\u062a\u0644\u0644\u064a \u06cc\u0627 metastatic \u062c\u0627\u0645\u062f \u062a\u0648\u0645\u0648\u0631\u0648\u0646\u0647 \u06cc\u06d0 \u0644\u0631\u0644 \u0627\u0648 \u062a\u0631 \u062f\u06d0 \u0645\u062e\u06a9\u06d0 \u06cc\u06d0 \u0685\u0648 \u062f\u0631\u0645\u0644\u0646\u06d0 \u0627\u062e\u06cc\u0633\u062a\u06d0 \u0648\u06d0\u060c \u062f Rezatapopt \u0639\u0645\u0648\u0645\u064a objective response rate \u0634\u0627\u0648\u062e\u0648\u0627 \u06f2\u06f0\u066a \u0648. \u067e\u0647 \u0647\u063a\u0648 \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u06a9\u06d0 \u0686\u06d0 \u062a\u0648\u0645\u0648\u0631 \u06cc\u06d0 KRAS-wild-type \u0648 \u0627\u0648 \u0644\u0696 \u062a\u0631 \u0644\u0696\u0647 \u067c\u0627\u06a9\u0644\u06d0 \u0645\u0624\u062b\u0631\u0647 \u062f\u0648\u0632 \u06cc\u06d0 \u0627\u062e\u06cc\u0633\u062a\u06cc \u0648\u060c response rate \u06f3\u06f0\u066a \u062a\u0647 \u0648\u0631\u0633\u06d0\u062f. \u0681\u0648\u0627\u0628\u0648\u0646\u0647 \u062f \u0628\u06d0\u0644\u0627\u0628\u06d0\u0644\u0648 \u062a\u0648\u0645\u0648\u0631\u0648\u0646\u0648\u060c \u067e\u0647 \u06ab\u0689\u0648\u0646 \u062f ovarian \u0627\u0648 breast cancer\u060c \u067e\u0647 \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u06a9\u06d0 \u0648\u0644\u06cc\u062f\u0644 \u0634\u0648\u0644. \u062f\u0627 \u0645\u0647\u0645 clinical proof-of-concept \u062f\u06cc: \u06cc\u0639\u0646\u06d0 \u062f \u06cc\u0648\u0647 \u062e\u0631\u0627\u0628 \u0634\u0648\u064a tumor-suppressor \u067e\u0631\u0648\u067c\u06cc\u0646 \u0645\u0633\u062a\u0642\u06cc\u0645 \u201c\u0628\u06cc\u0627 \u0641\u0639\u0627\u0644\u0648\u0644\u201d \u067e\u0647 \u0627\u0646\u0633\u0627\u0646 \u06a9\u06d0 \u0645\u0645\u06a9\u0646 \u06a9\u06d0\u062f\u0627\u06cc \u0634\u064a. \u062e\u0648 \u062f\u0627 \u062f \u067c\u0648\u0644\u0648 \u0633\u0631\u0637\u0627\u0646\u0648\u0646\u0648 \u0639\u0644\u0627\u062c \u0646\u0647 \u062f\u06cc\u060c \u0627\u0648 Rezatapopt \u0644\u0627 \u062a\u062d\u0642\u06cc\u0642\u064a \u062f\u0631\u0645\u0644 \u062f\u06cc. [8]<\/p>\n<p>\u06a9\u0627\u0645\u06cc\u0627\u0628\u064a \u0628\u0627\u06cc\u062f \u062f \u0645\u062d\u062f\u0648\u062f\u06cc\u062a\u0648\u0646\u0648 \u062a\u0631 \u0685\u0646\u06ab \u0648\u0644\u0648\u0633\u062a\u0644 \u0634\u064a. \u067e\u0647 \u0647\u0645\u062f\u06d0 Phase I \u06a9\u06d0 \u062a\u0631 \u067c\u0648\u0644\u0648 \u0639\u0627\u0645 \u0639\u0648\u0627\u0631\u0636 nausea\u060c vomiting\u060c \u062f creatinine \u0644\u0648\u0693\u0648\u0627\u0644\u06cc\u060c fatigue \u0627\u0648 anemia \u0648\u0648\u061b \u062f \u0644\u0648\u0693 \u062f\u0631\u062c\u06d0 anemia \u0647\u0645 \u0648\u0644\u06cc\u062f\u0644 \u0634\u0648\u0647. \u0644\u0647 \u0628\u0644\u06d0 \u062e\u0648\u0627\u060c \u062f \u06f2\u06f0\u06f2\u06f6 \u06cc\u0648\u06d0 peer-reviewed \u0644\u0627\u0628\u0631\u0627\u062a\u0648\u0627\u0631\u064a \u0685\u06d0\u0693\u0646\u06d0 \u0648\u069a\u0648\u062f\u0644\u0647 \u0686\u06d0 Rezatapopt \u062f Y220S mutant p53 \u0641\u0639\u0627\u0644\u06cc\u062a \u0647\u0645 \u067e\u0647 \u062d\u062c\u0631\u0648\u064a \u0645\u0627\u0689\u0644\u0648\u0646\u0648 \u06a9\u06d0 \u0628\u06d0\u0631\u062a\u0647 \u0631\u0627\u067e\u0627\u0631\u0648\u0644\u0627\u06cc \u0634\u064a\u060c \u062e\u0648 \u062f Y220N \u0644\u067e\u0627\u0631\u0647 \u06cc\u06d0 \u0627\u063a\u06d0\u0632 \u0689\u06d0\u0631 \u0645\u062d\u062f\u0648\u062f \u0648. \u062f\u0627 \u062f \u0631\u0627\u062a\u0644\u0648\u0646\u06a9\u064a \u0644\u067e\u0627\u0631\u0647 \u0645\u0647\u0645\u0647 \u0646\u069a\u0647 \u062f\u0647\u060c \u062e\u0648 \u0644\u0627 \u067e\u0647 \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u06a9\u06d0 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u062b\u0628\u0648\u062a \u0646\u0647 \u062f\u06cc. [11]<\/p>\n<p>\u0647\u0645\u062f\u0627\u0631\u0646\u06ab\u0647\u060c \u062f \u06f2\u06f0\u06f2\u06f6 \u067e\u0647 Cancer Discovery \u06a9\u06d0 \u062f \u062f\u0631\u0645\u0644\u0648 \u062f \u0645\u0642\u0627\u0648\u0645\u062a \u06cc\u0648\u0647 \u0645\u0647\u0645\u0647 \u0633\u062a\u0648\u0646\u0632\u0647 \u062b\u0628\u062a \u0634\u0648\u0647: \u062f Rezatapopt \u062a\u0631 \u0641\u0634\u0627\u0631 \u0644\u0627\u0646\u062f\u06d0 \u067e\u0647 \u0681\u06cc\u0646\u0648 \u062a\u0648\u0645\u0648\u0631\u0648\u0646\u0648 \u06a9\u06d0 \u062b\u0627\u0646\u0648\u064a TP53 \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0647 \u0631\u0627\u0645\u0646\u0681\u062a\u0647 \u06a9\u06d0\u062f\u0627\u06cc \u0634\u064a \u0686\u06d0 \u06cc\u0627 \u062f p53 \u0641\u0639\u0627\u0644\u06cc\u062a \u0644\u0647 \u0645\u0646\u0681\u0647 \u0648\u0693\u064a\u060c \u06cc\u0627 \u062f Y220C \u0647\u063a\u0647 \u062c\u06cc\u0628 \u0628\u062f\u0644\u0648\u064a \u0686\u06d0 \u062f\u0631\u0645\u0644 \u0648\u0631\u0633\u0631\u0647 \u0646\u069a\u0644\u064a. \u062f\u0627 \u0645\u0648\u0646\u062f\u0646\u0647 \u06cc\u0648 \u0645\u0647\u0645 \u062f\u0631\u0633 \u062f\u06cc: \u0647\u062f\u0641\u0645\u0646\u062f\u0647 \u062f\u0631\u0645\u0644\u0646\u0647 \u0642\u0648\u064a \u06a9\u06d0\u062f\u0627\u06cc \u0634\u064a\u060c \u062e\u0648 \u0633\u0631\u0637\u0627\u0646 \u0647\u0645 \u062f \u0641\u0631\u0627\u0631 \u0646\u0648\u06d0 \u0644\u0627\u0631\u06d0 \u067e\u06cc\u062f\u0627 \u06a9\u0648\u0644\u0627\u06cc \u0634\u064a. \u062f \u0647\u0645\u062f\u06d0 \u0645\u0642\u0627\u0648\u0645\u062a \u062f \u0645\u0627\u062a\u0648\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u0631\u0627\u062a\u0644\u0648\u0646\u06a9\u06cc \u0646\u0633\u0644 \u062f\u0631\u0645\u0644 \u0627\u0648 \u062a\u0631\u06a9\u06cc\u0628\u064a \u062a\u06ab\u0644\u0627\u0631\u06d0 \u0627\u0693\u062a\u06cc\u0627 \u0644\u0631\u064a. [12]<\/p>\n<p>\u06f1\u06f1. \u0622\u06cc\u0627 \u0633\u0631\u0637\u0627\u0646 \u062f \u0648\u06cc\u0646\u06d0 \u0644\u0647 \u06cc\u0648\u0647 \u067c\u06cc\u0648\u0628 \u0685\u062e\u0647 \u062a\u0631 \u062a\u0635\u0648\u06cc\u0631 \u0645\u062e\u06a9\u06d0 \u0645\u0648\u0646\u062f\u0644 \u06a9\u06d0\u062f\u0627\u06cc \u0634\u064a\u061f<\/p>\n<p>\u062f Liquid Biopsy \u0627\u0648 circulating tumor DNA (ctDNA) \u067e\u0631\u0645\u062e\u062a\u06ab \u062f \u0633\u0631\u0637\u0627\u0646 \u062f \u062a\u0634\u062e\u06cc\u0635 \u0627\u0648 \u0685\u0627\u0631\u0646\u06d0 \u06cc\u0648\u0647 \u0645\u0647\u0645\u0647 \u0646\u0648\u06d0 \u0644\u0627\u0631\u0647 \u062f\u0647. \u0633\u0631\u0637\u0627\u0646\u064a \u062d\u062c\u0631\u06d0 \u062f \u062e\u067e\u0644 DNA \u0648\u0627\u0693\u0647 \u067c\u0648\u067c\u06d0 \u0648\u06cc\u0646\u06d0 \u062a\u0647 \u062e\u0648\u0634\u06d0 \u06a9\u0648\u064a\u061b \u0689\u06d0\u0631 \u062d\u0633\u0627\u0633 \u0627\u0632\u0645\u0648\u06cc\u0646\u06d0 \u06a9\u0648\u0644\u0627\u06cc \u0634\u064a \u062f\u0627 \u0646\u069a\u06d0 \u0648\u0645\u0648\u0645\u064a. \u067e\u0647 \u0681\u06cc\u0646\u0648 \u062c\u0627\u0645\u062f\u0648 \u062a\u0648\u0645\u0648\u0631\u0648\u0646\u0648 \u06a9\u06d0 ctDNA \u062f \u0639\u0645\u0644\u06cc\u0627\u062a\u0648 \u06cc\u0627 \u062f\u0631\u0645\u0644\u0646\u06d0 \u0648\u0631\u0648\u0633\u062a\u0647 \u062f Minimal Residual Disease (MRD) \u0646\u069a\u0647 \u062a\u0631 CT \u06cc\u0627 \u0646\u0648\u0631\u0648 \u062a\u0635\u0648\u06cc\u0631\u0648\u0646\u0648 \u0685\u0648 \u0645\u06cc\u0627\u0634\u062a\u06d0 \u0645\u062e\u06a9\u06d0 \u0685\u0631\u06ab\u0646\u062f\u0648\u0644\u0627\u06cc \u0634\u064a. \u062f\u0627 \u067e\u0647 \u0681\u0627\u0646\u06ab\u0693\u064a \u0689\u0648\u0644 \u062f relapse \u062f \u062e\u0637\u0631 \u062f \u0645\u0639\u0644\u0648\u0645\u0648\u0644\u0648 \u0627\u0648 \u062f \u0646\u0627\u0631\u0648\u063a \u062f \u0646\u0696\u062f\u06d0 \u0685\u0627\u0631\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647 \u0689\u06d0\u0631 \u0647\u06cc\u0644\u0647\u200c\u0645\u0646 \u062f\u06cc. \u062e\u0648 \u062f\u0627 \u0644\u0627 \u062f \u067c\u0648\u0644\u0648 \u0633\u0627\u0644\u0645\u0648 \u062e\u0644\u06a9\u0648 \u0644\u067e\u0627\u0631\u0647 \u062f \u0647\u0631 \u0689\u0648\u0644 \u0633\u0631\u0637\u0627\u0646 \u0628\u0634\u067e\u0693 screening test \u0646\u0647 \u062f\u06cc\u061b \u062f \u062f\u06d0 \u0644\u067e\u0627\u0631\u0647 \u0644\u0627 \u0646\u0648\u0631\u0648 \u062a\u0635\u0627\u062f\u0641\u064a \u0627\u0648 interventional \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0685\u06d0\u0693\u0646\u0648 \u062a\u0647 \u0627\u0693\u062a\u06cc\u0627 \u0634\u062a\u0647. [9]<\/p>\n<p>\u06f1\u06f2. \u0622\u06cc\u0627 \u062f\u0631\u0645\u0644 \u0627\u0648\u0633 \u062a\u0631 \u0689\u06d0\u0631\u0647 \u0633\u0631\u0637\u0627\u0646\u064a \u062d\u062c\u0631\u06d0 \u062a\u0647 \u0645\u0633\u062a\u0642\u06cc\u0645 \u0631\u0633\u0648\u0644 \u06a9\u06d0\u062f\u0627\u06cc \u0634\u064a\u061f<\/p>\n<p>Antibody\u2013Drug Conjugates (ADCs) \u062f \u0647\u062f\u0641\u0645\u0646\u062f\u06d0 \u062f\u0631\u0645\u0644\u0646\u06d0 \u0644\u0647 \u0686\u067c\u06a9 \u067e\u0631\u0645\u062e\u062a\u06ab\u0648\u0646\u0648 \u0685\u062e\u0647 \u062f\u064a. \u067e\u0647 \u062f\u06d0 \u0633\u06cc\u0633\u062a\u0645 \u06a9\u06d0 \u06cc\u0648 antibody \u062f \u0633\u0631\u0637\u0627\u0646\u064a \u062d\u062c\u0631\u06d0 \u0681\u0627\u0646\u06ab\u0693\u06cc target \u067e\u06d0\u0698\u0646\u064a \u0627\u0648 \u0648\u0631\u0633\u0631\u0647 \u06cc\u0648 \u0642\u0648\u064a cytotoxic \u062f\u0631\u0645\u0644 \u062a\u0693\u0644\u06cc \u0648\u064a\u061b \u0647\u062f\u0641 \u062f\u0627 \u062f\u06cc \u0686\u06d0 \u062f \u062f\u0631\u0645\u0644\u0648 \u0644\u0648\u0693\u0647 \u0628\u0631\u062e\u0647 \u062a\u0648\u0645\u0648\u0631 \u062a\u0647 \u0648\u0631\u0633\u06d0\u0696\u064a \u0627\u0648 \u0633\u0627\u0644\u0645 \u0646\u0633\u062c \u062a\u0647 \u0632\u06cc\u0627\u0646 \u062a\u0631 \u0645\u0645\u06a9\u0646\u0647 \u062d\u062f\u0647 \u06a9\u0645 \u0634\u064a. ADCs \u067e\u0647 \u0681\u0627\u0646\u06ab\u0693\u064a \u0689\u0648\u0644 \u062f \u0633\u06cc\u0646\u06d0 \u0627\u0648 \u0681\u06cc\u0646\u0648 \u0646\u0648\u0631\u0648 \u0633\u0631\u0637\u0627\u0646\u0648\u0646\u0648 \u067e\u0647 \u062f\u0631\u0645\u0644\u0646\u0647 \u06a9\u06d0 \u0645\u0647\u0645 \u0681\u0627\u06cc \u067e\u06cc\u062f\u0627 \u06a9\u0693\u06cc \u0627\u0648 \u0646\u0648\u064a \u0646\u0633\u0644\u0648\u0646\u0647 \u06cc\u06d0 \u067e\u0647 \u0686\u067c\u06a9\u06cd \u0633\u0631\u0647 \u067e\u0631\u0627\u062e\u06d0\u0696\u064a. \u0633\u0631\u0647 \u0644\u0647 \u062f\u06d0\u060c \u0645\u0642\u0627\u0648\u0645\u062a\u060c off-target effects \u0627\u0648 toxicity \u0644\u0627 \u0647\u0645 \u0645\u0647\u0645 \u0645\u062d\u062f\u0648\u062f\u06cc\u062a\u0648\u0646\u0647 \u062f\u064a. [10]<\/p>\n<p>\u06f1\u06f3. \u062f \u062f\u06d0 \u0628\u062d\u062b \u0627\u0635\u0644\u064a \u0639\u0644\u0645\u064a \u067e\u06cc\u063a\u0627\u0645 \u0685\u0647 \u062f\u06cc\u061f<\/p>\n<p>TP53 \u0627\u0648 p53 \u062f\u0648\u0647 \u062c\u0644\u0627 \u062c\u06cc\u0646\u0648\u0646\u0647 \u0646\u0647 \u062f\u064a. TP53 \u062f \u062c\u06cc\u0646 \u0631\u0633\u0645\u064a \u0646\u0648\u0645 \u062f\u06cc \u0627\u0648 p53 \u062f \u0647\u063a\u0647 \u067e\u0631\u0648\u067c\u06cc\u0646 \u062f\u06cc. \u062f\u0627 \u0633\u06cc\u0633\u062a\u0645 \u067e\u0647 \u06f1\u06f9\u06f7\u06f9 \u06a9\u0627\u0644 \u06a9\u06d0 \u062f \u0685\u0648 \u062e\u067e\u0644\u0648\u0627\u06a9\u0648 \u0685\u06d0\u0693\u0646\u06cc\u0632\u0648 \u0689\u0644\u0648 \u0644\u0647 \u062e\u0648\u0627 \u0648\u0645\u0648\u0646\u062f\u0644 \u0634\u0648\u060c \u0627\u0648 \u0648\u0631\u0648\u0633\u062a\u0647 \u0632\u0631\u06ab\u0648\u0646\u0648 \u0685\u06d0\u0693\u0646\u0648 \u0648\u069a\u0648\u062f\u0644\u0647 \u0686\u06d0 p53 \u062f DNA \u062f \u0632\u06cc\u0627\u0646\u060c \u062f \u062d\u062c\u0631\u06d0 \u062f \u0648\u06d0\u0634 \u0627\u0648 \u062f \u0633\u0631\u0637\u0627\u0646\u064a \u0628\u062f\u0644\u0648\u0646 \u062f \u0645\u062e\u0646\u06cc\u0648\u064a \u067e\u0647 \u0628\u0631\u062e\u0647 \u06a9\u06d0 \u0645\u0631\u06a9\u0632\u064a \u0631\u0648\u0644 \u0644\u0631\u064a.<\/p>\n<p>\u062a\u0631 \u06f2\u06f0\u06f2\u06f6 \u067e\u0648\u0631\u06d0 \u062f\u0631\u06d0 \u0644\u0648\u06cc \u067e\u0631\u0645\u062e\u062a\u06ab\u0648\u0646\u0647 \u0681\u0627\u0646\u06ab\u0693\u06d0 \u067e\u0627\u0645\u0644\u0631\u0646\u0647 \u063a\u0648\u0627\u0693\u064a: \u062f \u0681\u0627\u0646\u06ab\u0693\u064a mutant p53 \u0645\u0633\u062a\u0642\u06cc\u0645 \u0628\u06cc\u0627 \u0641\u0639\u0627\u0644\u0648\u0644\u060c \u062f ctDNA \u0644\u0647 \u0644\u0627\u0631\u06d0 \u062f \u067e\u0627\u062a\u06d0 \u06cc\u0627 \u0628\u06d0\u0631\u062a\u0647 \u0631\u0627\u06ab\u0631\u0681\u06d0\u062f\u0648\u0646\u06a9\u064a \u0633\u0631\u0637\u0627\u0646 \u0698\u0631 \u06a9\u0634\u0641\u060c \u0627\u0648 \u062f ADCs \u0644\u0647 \u0644\u0627\u0631\u06d0 \u0647\u062f\u0641\u0645\u0646\u062f \u062f\u0631\u0645\u0644 \u0631\u0633\u0648\u0644. \u0648\u0631\u0633\u0631\u0647 \u06cc\u0648 \u0685\u0644\u0648\u0631\u0645 \u0645\u0647\u0645 \u062f\u0631\u0633 \u0647\u0645 \u0631\u0648\u069a\u0627\u0646\u0647 \u0634\u0648\u06cc: \u062d\u062a\u06cc \u0689\u06d0\u0631 \u062f\u0642\u06cc\u0642 targeted therapy \u0647\u0645 \u062f \u0645\u0642\u0627\u0648\u0645\u062a \u0644\u0647 \u0633\u062a\u0648\u0646\u0632\u06d0 \u0633\u0631\u0647 \u0645\u062e \u06a9\u06d0\u062f\u0627\u06cc \u0634\u064a\u060c \u0646\u0648 \u062f \u0631\u0627\u062a\u0644\u0648\u0646\u06a9\u064a \u067e\u0631\u0645\u062e\u062a\u06ab \u0645\u0639\u06cc\u0627\u0631 \u06cc\u0648\u0627\u0632\u06d0 \u201c\u062f\u0631\u0645\u0644 \u0634\u062a\u0647\u201d \u0646\u0647 \u062f\u06cc\u060c \u0628\u0644\u06a9\u06d0 \u062f\u0627 \u062f\u06cc \u0686\u06d0 \u0685\u0648\u06a9 \u062a\u0631\u06d0 \u06ab\u067c\u0647 \u0627\u062e\u0644\u064a\u060c \u0685\u0648\u0645\u0631\u0647 \u0645\u0648\u062f\u0647\u060c \u067e\u0647 \u06a9\u0648\u0645 mutation \u06a9\u06d0\u060c \u0627\u0648 \u062f \u0645\u0642\u0627\u0648\u0645\u062a \u067e\u0631 \u0645\u0647\u0627\u0644 \u0685\u0647 \u0628\u0627\u06cc\u062f \u0648\u0634\u064a.<\/p>\n<p>\u062f\u0627 \u067e\u0631\u0645\u062e\u062a\u06ab\u0648\u0646\u0647 \u0647\u06cc\u0644\u0647\u200c\u0645\u0646 \u062f\u064a\u060c \u062e\u0648 \u0647\u0631 \u06cc\u0648 \u062e\u067e\u0644 \u062d\u062f\u0648\u062f \u0644\u0631\u064a. \u0639\u0644\u0645\u064a \u0627\u0639\u062a\u0628\u0627\u0631 \u0647\u063a\u0647 \u0648\u062e\u062a \u0633\u0627\u062a\u0644 \u06a9\u06d0\u0696\u064a \u0686\u06d0 \u062f \u062a\u062c\u0631\u0628\u0648\u064a \u0627\u0645\u06cc\u062f\u060c \u0644\u0648\u0645\u0693\u0646\u064a \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a signal \u0627\u0648 \u062b\u0627\u0628\u062a standard-of-care \u062a\u0631\u0645\u0646\u0681 \u0631\u0648\u069a\u0627\u0646\u0647 \u062a\u0648\u067e\u06cc\u0631 \u0648\u0634\u064a.<\/p>\n<\/div>\n<div dir=\"rtl\">\n<div>\n<p>\u067e\u0647 \u06cc\u0648\u0647 \u0646\u0638\u0631 \u06a9\u06d0<\/p>\n<p>\u2022 TP53 = \u062c\u06cc\u0646 (DNA)<\/p>\n<p>\u2022 p53 = \u062f TP53 \u067e\u0631\u0648\u067c\u06cc\u0646\u064a \u0645\u062d\u0635\u0648\u0644 \u0627\u0648 \u0645\u0647\u0645 Tumor Suppressor<\/p>\n<p>\u2022 Rezatapopt = \u062f TP53 Y220C \u0644\u067e\u0627\u0631\u0647 \u0685\u06d0\u0693\u0646\u06cc\u0632 p53 reactivator\u061b \u062a\u0631 \u06f2\u06f0\u06f2\u06f6 \u067e\u0648\u0631\u06d0 clinical proof-of-concept \u0634\u062a\u0647\u060c \u062e\u0648 \u0639\u0645\u0648\u0645\u064a \u0639\u0644\u0627\u062c \u0646\u0647 \u062f\u06cc<\/p>\n<p>\u2022 Y220S = \u067e\u0647 \u06f2\u06f0\u06f2\u06f6 preclinical \u0685\u06d0\u0693\u0646\u0647 \u06a9\u06d0 \u062f Rezatapopt \u0644\u0647 \u062e\u0648\u0627 \u062f \u0628\u06cc\u0627 \u0641\u0639\u0627\u0644\u06d0\u062f\u0648 \u0646\u069a\u06d0\u061b \u0644\u0627 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u062b\u0628\u0648\u062a \u0646\u0634\u062a\u0647<\/p>\n<p>\u2022 ctDNA = \u062f \u0648\u06cc\u0646\u06d0 \u0644\u0647 \u0644\u0627\u0631\u06d0 \u062f \u062a\u0648\u0645\u0648\u0631 \u062f \u062c\u06cc\u0646\u064a \u0646\u069a\u0648 \u0627\u0648 MRD \u0645\u0648\u0646\u062f\u0646\u0647<\/p>\n<p>\u2022 ADC = antibody + \u0647\u062f\u0641\u0645\u0646\u062f cytotoxic \u062f\u0631\u0645\u0644<\/p>\n<p>\u2022 \u0645\u0642\u0627\u0648\u0645\u062a = \u0633\u0631\u0637\u0627\u0646 \u06a9\u0648\u0644\u0627\u06cc \u0634\u064a \u062d\u062a\u06cc \u062f p53-targeted \u062f\u0631\u0645\u0644\u0646\u06d0 \u067e\u0631 \u0648\u0693\u0627\u0646\u062f\u06d0 \u062b\u0627\u0646\u0648\u064a \u062c\u06cc\u0646\u064a \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0647 \u0631\u0627\u0645\u0646\u0681\u062a\u0647 \u06a9\u0693\u064a<\/p>\n<\/div>\n<\/div>\n<div dir=\"rtl\">\n<div>\n<p>\u00a0\u0633\u0631\u0686\u06cc\u0646\u06d0<\/p>\n<p>1. Lane DP, Crawford LV. T antigen is bound to a host protein in SV40-transformed cells. Nature. 1979;278:261-263. doi:10.1038\/278261a0.<\/p>\n<p>2. Linzer DIH, Levine AJ. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 1979;17:43-52. doi:10.1016\/0092-8674(79)<wbr \/>90293-9.<\/p>\n<p>3. DeLeo AB, Jay G, Appella E, et al. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci USA. 1979;76:2420-2424. doi:10.1073\/pnas.76.5.2420.<\/p>\n<p>4. Baker SJ, Fearon ER, Nigro JM, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science. 1989;244:217-221. doi:10.1126\/science.2649981.<\/p>\n<p>5. NCBI Gene. TP53 tumor protein p53 [Homo sapiens]. Gene ID 7157. Official symbol TP53; genomic location 17p13.1. National Center for Biotechnology Information. Updated 15 Sep 2026.<\/p>\n<p>6. Lane DP. Cancer. p53, guardian of the genome. Nature. 1992;358:15-16. doi:10.1038\/358015a0.<\/p>\n<p>7. Puzio-Kuter AM, Xu L, McBrayer MK, et al. Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator. Cancer Discovery. 2025;15:1159-1179. doi:10.1158\/2159-8290.CD-24-<wbr \/>1421.<\/p>\n<p>8. Dumbrava EE, Shapiro GI, Parikh AR, et al. Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C-Mutated Tumors. New England Journal of Medicine. 2026;394:872-883. doi:10.1056\/NEJMoa2508820.<\/p>\n<p>9. Pantel K, Alix-Panabi\u00e8res C. Minimal residual disease as a target for liquid biopsy in patients with solid tumours. Nature Reviews Clinical Oncology. 2025;22:65-77. doi:10.1038\/s41571-024-00967-<wbr \/>y.<\/p>\n<p>10. Zippelius A, Tolaney SM, Tarantino P, et al. Unveiling the molecular and immunological drivers of antibody-drug conjugates in cancer treatment. Nature Reviews Cancer. 2025;25:925-944. doi:10.1038\/s41568-025-00869-<wbr \/>w.<\/p>\n<p>11. Mavridi D, Funk JS, Balourdas DI, et al. Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt. Cell Death &amp; Disease. 2026;17:268. doi:10.1038\/s41419-026-08492-<wbr \/>9.<\/p>\n<p>12. Fece de la Cruz F, Varkaris A, Patel PS, et al. Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators. Cancer Discovery. 2026;16:677-685. doi:10.1158\/2159-8290.CD-25-<wbr \/>1761.<\/p>\n<p>Page<\/p>\n<\/div>\n<div dir=\"ltr\" style=\"text-align: right;\">\u0645\u062d\u0645\u062f \u0647\u0645\u0627\u06cc\u0648\u0646 \u0647\u0645\u062a<\/div>\n<div dir=\"ltr\" style=\"text-align: right;\">MD., PhD<\/div>\n<\/div>\n<\/div>\n<div dir=\"ltr\">\n<div dir=\"rtl\">\n<div dir=\"ltr\" style=\"text-align: right;\">\u06f3\u06f0 \u0633\u067e\u062a\u0645\u0628\u0631 \u00a0\u06f2\u06f0\u06f2\u06f6<\/div>\n<\/div>\n<\/div>\n<blockquote class=\"wp-embedded-content\" data-secret=\"jZEz1T4iUb\"><p><a href=\"https:\/\/af.dawatmedia24.com\/?p=190030\">\u06a9\u0627\u0628\u0644 \u067e\u0647 \u06cc\u0648\u0647 \u0648\u0631\u0681 \u0648\u0646\u0647 \u0646\u0693\u06d0\u062f<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u201c\u06a9\u0627\u0628\u0644 \u067e\u0647 \u06cc\u0648\u0647 \u0648\u0631\u0681 \u0648\u0646\u0647 \u0646\u0693\u06d0\u062f\u201d \u2014 DawatMedia24\" src=\"https:\/\/af.dawatmedia24.com\/?p=190030&amp;embed=true#?secret=qapjYLqYj3#?secret=jZEz1T4iUb\" data-secret=\"jZEz1T4iUb\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p dir=\"rtl\" style=\"text-align: center;\"><strong>\u0632\u0645\u0648\u0696 \u0627\u0646\u06ab\u0644\u06cc\u0633\u064a \u0648\u06cc\u0628\u067e\u0627\u06bc\u0647:\u00a0<\/strong><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/dawatmedia24.com\/\"><img class=\"wp-image-177249 aligncenter b-loaded\" sizes=\"(max-width: 169px) 100vw, 169px\" srcset=\"https:\/\/af.dawatmedia24.com\/wp-content\/uploads\/2025\/08\/logo-english-dawat-300x117.jpg 300w, https:\/\/af.dawatmedia24.com\/wp-content\/uploads\/2025\/08\/logo-english-dawat.jpg 405w\" alt=\"\" width=\"169\" height=\"66\" data-srcset=\"https:\/\/af.dawatmedia24.com\/wp-content\/uploads\/2025\/08\/logo-english-dawat-300x117.jpg 300w, https:\/\/af.dawatmedia24.com\/wp-content\/uploads\/2025\/08\/logo-english-dawat.jpg 405w\" data-src=\"https:\/\/af.dawatmedia24.com\/wp-content\/uploads\/2025\/08\/logo-english-dawat-300x117.jpg\" \/><\/a><\/p>\n<div dir=\"auto\">\n<p dir=\"rtl\" style=\"text-align: center;\">\u00a0\u00a0<a href=\"https:\/\/donate.stripe.com\/5kQcN56m53Pgapae234Rq00\"><strong>Donate Here<\/strong><\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>TP53 \u0627\u0648 p53 \u0685\u0647 \u062f\u064a\u061f \u062f \u0633\u0631\u0637\u0627\u0646 \u0637\u0628\u06cc\u0639\u064a \u062f\u069a\u0645\u0646 \u0685\u0646\u06ab\u0647 \u062f \u0646\u0648\u06d0 \u0647\u062f\u0641\u0645\u0646\u062f\u06d0 \u062f\u0631\u0645\u0644\u0646\u06d0 \u067e\u0647 \u062f\u0631\u0648\u0627\u0632\u0647 \u0628\u062f\u0644 \u0634\u0648\u061f \u0644\u0647 \u06f1\u06f9\u06f7\u06f9 \u06a9\u0634\u0641 \u0685\u062e\u0647 \u062a\u0631 \u06f2\u06f0\u06f2\u06f6 \u067e\u0648\u0631\u06d0: Rezatapopt\u060c ctDNA \u0627\u0648 ADCs &#8211; \u0685\u0647 \u062b\u0627\u0628\u062a \u062f\u064a\u060c \u0685\u0647 \u0647\u06cc\u0644\u0647\u200c\u0645\u0646 \u062f\u064a\u060c \u0627\u0648 \u0685\u0647 \u0644\u0627 \u0685\u06d0\u0693\u0646\u06cc\u0632 \u062f\u064a\u061f &nbsp; \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":186143,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[45],"tags":[12704,12705],"class_list":["post-190085","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-45","tag-12704","tag-12705"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - 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